BNTA NO FURTHER A MYSTERY

The neurologic phenotype in SCA8 BAC enlargement although not BAC Regulate lines demonstrated the pathogenicity with the (CTG-CAG)n expansion. Also, the expression of noncoding (CUG)n enlargement ATXN8OS transcripts and the invention of intranuclear polyglutamine inclusions prompt that SCA8 pathogenesis includes toxic attain-of-function mechanisms